Sodium Cholate
ICE NZPOverview
Sodium Cholate (NaC) is the sodium salt of Cholic Acid, the most abundant bile acid naturally found in human bile. As an amphiphilic compound, it plays a key role in solubilizing lipids and enhancing drug absorption.
ICE Pharma produces high-purity, GMP-compliant Sodium Cholate through a robust extraction and purification process using bovine bile as the natural source. This ensures pharmaceutical-grade consistency and performance across industrial and life science applications.
Applications
Sodium Cholate is a versatile bile salt with several established applications:
- Microbiological Media: used in the formulation of selective diagnostic media, particularly for cultivating intestinal bacteria.
- Protein Extraction & Purification: functions as a manufacturing aid in bioprocessing workflows, helping extract and stabilize membrane proteins.
- Pharmaceutical Formulations: NaC acts as stabilizer, solubilizer and permeation enhancer excipient, thus resulting as a bioavailability enhancer in in several routes of administration.
End Uses
Sodium Cholate is used in a variety of scientific and pharmaceutical applications. It plays a key role in the preparation of microbiological diagnostic media, particularly for cultivating and identifying intestinal microorganisms. In biomanufacturing, it serves as a processing aid for the extraction and purification of proteins, especially membrane-bound proteins.
Additionally, Sodium Cholate is used as an excipient in certain drug formulations to improve the bioavailability of drugs through micelle formation or formulating various drug delivery systems.
Manufacturing and Quality Assurance
Our high-purity Sodium Cholate is manufactured at ICE Pharma’s state-of-the-art facilities in Italy and New Zealand, operating under stringent GMP standards. Each batch undergoes rigorous quality control to ensure high purity, consistency, and safety.
Regulatory Compliance
Our commitment to quality, compliance, and safety ensures that our Sodium Cholate meets global pharmaceutical industry standards, making it a reliable choice for pharmaceutical applications worldwide.
- GMP Compliance: Yes
- DMF Available: Yes (API grade), Yes (excipient Japanese DMF)
- BSE/TSE CEP: Yes, of the starting material
- Product overview
- End Uses
- Manufacturing Sites
Product Overview
CAS Number
361-09-1, 206986-87-0 (sodium cholate hydrate)
EC Number
206-643-5
Molecular Formula
C24H39NaO5
Molecular Weight
430.56
Synonyms
3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid sodium salt, Cholic acid sodium salt
MDL Number
MFCD00064138, MFCD00150749 (sodium cholate hydrate)
INCHL
NRHMKIHPTBHXPF-TUJRSCDTSA-M
UNII
NU3Y4CCH8Z
Form
white powder or white microcrystalline powder
End Uses
Sodium cholate is used in the preparation and formulation of certain microbiological diagnostic media. It is used as a manufacturing aid for the extraction and purification of proteins. It is also used as an excipient in certain drug formulations to improve drug bioavailability.
Manufacturing Sites
Sites |
Grade |
Packaging |
Standard Specification |
GMP Compliant |
DMF Available |
Chemical CEP |
BSETSE CEP |
|---|---|---|---|---|---|---|---|
New Zealand |
N/A |
20 kg polyethylene plastic/foil liner in Darbox |
N/A |
Yes |
No |
No |
Yes |
Basaluzzo - Italy |
N/A |
10 kg polyethylene/heat-sealed aluminium bags in a fibre drum |
N/A |
Yes |
Yes |
No |
Yes |
Reggio Emilia - Italy |
N/A |
25 kg double polyethylene bags in a fibre or plastic drum |
N/A |
Yes |
No |
No |
Yes |