We offer a comprehensive custom synthesis service to take your project from discovery to clinical trial
Our core expertise includes complex oligosaccharide chemistry, route design, process development, optimisation and scale-up, process validation, technology transfer and GMP manufacture for Phase 1 and Phase 2 clinical trials. Our fully equipped analytical laboratories offer expert support with a comprehensive range of analytical techniques available.
All activities are fully supported by a strong Quality Management System and Health & Safety Framework and we have successfully achieved ISO9001:2015 registration.
Our core technologies include:
- Route design
- Excellence in process development, optimisation and scale-up
- Process validation
- Effective multi-step synthesis
- Technology transfer
Specialist manufacturing capabilities in:
- sugar – protein/solid support conjugation chemistry
- oxidation reactions
- imino sugars
- unnatural L-sugars
- hydrogenation reactions
At Dextra we understand drug development programs are complex, challenging and that it all begins with an effective discovery phase.
We’ll evaluate candidate structures, provide expert advice on synthetic viability and complete the synthesis of early targets.
Our research and development team look for creative ways to prepare your compounds. We design synthetic routes and evaluate their viability with longer term goals of efficient, sustainable and robust process in mind.
We are experts in process development, problem-solving, optimisation and scale up. We look for innovative solutions to provide simplified processes and build in robustness.
Our synthetic services are fully integrated from discovery chemistry, through the pre-clinical development phase and on to GMP manufacture. This ensures efficient supply of material with appropriate control over the impurity profile.
At our Reading site, we offer full cGMP manufacturing to support Phase 1 and Phase 2 clinical trials.
Blood Group Products
Dextra have proven expertise in the manufacture of a wide variety of blood group products, from the standard blood group oligosaccharides, to those functionalised with a selection of linker arms.
Naturally occurring glycoconjugates are known to be ubiquitous in nature and are vitally important in many biological processes including in cell-cell recognition and biological messaging.
Dextra offers a wide range of glycans, blood group oligosaccharides and human milk oligosaccharides along with a wide range of specialty compounds.
Our range includes an extensive collection of phosphorylated sugars, sulfated sugars, halogenated sugars, iminosugars, protected intermediates and unusual lactones available as building blocks and basic research tools.
Nucleosides & Nucleotides
Naturally occurring nucleosides and nucleotides are ubiquitous in nature and are critical to DNA/RNA replication.
Polysaccharides are large polymers of repeating monosaccharide or disaccharide units. Dextra offers a wide variety of plant, microbial and animal derived acidic and neutral polysaccharides.
Chief Scientific Officer
Business Development Manager
Head of Chemistry
Alex completed his graduate and postgraduate education at the University of Reading receiving his PhD in 1993 under the supervision of Professor John Mann. With over 20 years' experience in the fine chemical industry at Dextra, Isochem and CMS, Alex has extensive synthetic experience developing innovative scalable routes to key intermediates and API's predominately in the field of carbohydrates. Alex was appointed Chief Scientific Officer of Dextra and NZP in 2011.
Kylie joined Dextra as a synthetic chemist in 2012 following completion of her PhD in organic chemistry at the University of Southampton under the supervision of Professor Bruno Linclau. Kylie joined the commercial team at NZP in 2017 becoming Business Development Manager for Dextra in January 2022.
Andrew joined Dextra Laboratories in 2010 having previously worked for Onyx Scientific. He has broad background in synthetic organic chemistry and process development having studied at the University of Oxford for both his undergraduate masters and doctoral degrees. He completed his DPhil in organic chemistry under the supervision of Jeremy Robertson in 2008. Andrew leads the carbohydrate chemistry team and has responsibility for the GMP facility in Reading.
Dextra Laboratories Ltd
Thames Valley Science Park
1 Collegiate Square
Reading RG2 9LH
Main line+44 (0)118 304 1100
Get in touch with Dextra today