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Doxophylline

ABC

Doxofylline is a methylxanthine bronchodilator with potent bronchodilator activity comparable to that of theophylline. In animal studies, doxofylline demonstrated to attenuate bronchoconstriction, inflammatory actions and the release of thromboxane A2 (TXA2) when challenged with platelet-activating factor. Doxofylline does not demonstrate direct inhibition of any histone deacetylase (HDAC) enzymes or known PDE enzyme isoforms and did not act as an antagonist at A2 or A2 receptors. The affinity for adenosine A1, A2A and A2B receptors are reported to be all higher than 100 μM. It only displays an inhibitory action against PDE2A1 and antagonism at adenosine A(2A) at high concentrations. A study demonstrated that doxofylline interacts with β2-adrenoceptors to induce blood vessel relaxation and airway smooth muscle relaxation. In dog studies, doxofylline decreased airway responsiveness at a dose that did not affect heart rate and respiratory rate.

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  • Product overview
  • End Uses
  • Manufacturing Sites

Products Overview

  • CAS Number

    69975-86-6

  • EC Number

    274-239-6

  • Molecular Formula

    C11H14N4O4

  • Molecular Weight

    266.26

  • Synonyms

    Doxophylline

  • MDL Number

    MFCD00865218

End Uses

Doxofylline is a xanthine molecule having both bronchodilator and anti-inflammatory activities. Doxofylline mechanism of action consists of its ability to selectively inhibit phosphodiesterases (PDE III, IV,V) and not the adenosine receptors, A1 and A2.

Manufacturing Sites

Sites
Grade
Packaging
Standard Specification
GMP Compliant
DMF Available
Chemical CEP
BSETSE CEP

ABC FARMACEUTICI

N/A

25kg

N/A

Yes

Yes

No

No

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